Starring Natalie Portman, Oscar Isaac, Jennifer Jason Leigh, Gina Rodriguez, Tuva Novotny, and Tessa Thompson, Annihilation is about a biologist who signs up for a dangerous, secret expedition into a mysterious zone where the laws of nature don't apply. Directed by Alex Garland, who also directed Ex-Machina, Dredd, and Sunshine, more good sci-fi action movies, it was clear from the start that this story was well within his wheelhouse.